So there’s this paper I’ve been trying to get published for a little while. It lays out my hypothesis for why we age. You can see the preprint here on the bioRxiv server. The journal editors really don’t seem to like it, probably because it is completely against the grain of current thinking, although a handful of people who have seen it on bioRxiv seem to like it quite a bit.
In the past, I had never been that interested in aging, because I get depressed when I think about degenerative diseases. I think it comes from when I was training as a doctor and I would see patient after patient with hypertension, diabetes, and heart disease. The older doctors taught me that our job was not to cure these patients–that was impossible–but to slow down the inevitable progression of these diseases. I didn’t like that. I like to fix people, I like to fix problems, I like to fix companies.
But my interest was piqued when I read a review article in Science couple of years ago that declared that it was just a matter of time before we could reverse aging. Continue reading “Why Do We Age? Because of Parasites. Or, the Red King Theory”
Let’s talk about what happened when Europeans first tried to settle North America. They failed and never came back. The entire Eastern seaboard was covered Native American farms and there was hardly a fertile spot left. And the Native Americans overwhelmed the settlers and drove them out.
I am, of course, talking about the Vikings who tried to settle Newfoundland and failed.
Continue reading “Hand of God or A Viral Shockwave?”
We were taught in medical school that the bladder was sterile. That’s because urine is sterile. So naturally, so is the bladder, right?
Wrong. It turns out that there are numerous organisms in the bladder, and that probiotics that might change the microbiome in the bladder may enhance effectiveness of chemotherapy for bladder cancer.
The reason we thought bladder was sterile is Continue reading “If You Can’t Culture It, It Doesn’t Exist”
Westley: “Ha! Your pig fiance is too late. A few more steps and we’ll be safe in the fire swamp.”
Buttercup: “We’ll never survive.”
Westley: “Nonsense. You’re only saying that because no one ever has.”
– from: Princess Bride, via 25iq.com
If you took physics in high school, you learned that it was impossible to see anything smaller than half the wavelength of light, no matter how powerful the microscope. This limitation is a hard, fixed law of physics, not a matter of how good the microscope is. It’s just a law of nature, proven mathematically by Ernst Abbe in 1873.
Except Betzig and Hell figured out how to break this law, for which they won Continue reading “Almost Impossible”
“All I wanted was the opportunity to fail” – Jack Goeken, Founder of MCI
You can’t have successes without risking failure
When medical students are taught about appendicitis, we are taught that 20% of the appendectomies should find that the appendix does not need to removed. In other words, we should have such a low threshold for surgery that in 20% of the cases, we should be wrong. If only 10% of the surgeries are wrong, we are killing patients because Continue reading “Power of Failure”
There are some observations from animal health that poses questions for human medicine and in some cases possess challenges to the current paradigm.
For example, let’s take gingivitis. We think of gingivitis as a degenerative disease, caused by bacteria. But dogs get gingivitis, with all the attendant sequelae, including tooth loss. But the speed at which the disease progresses is much Continue reading “Questions from OneHealth”
Simpson’s Paradox is one of the classic paradoxes, made famous by the UC Berkeley’s experience,
In 1973, the admission rate for men and women were noted to be very different for UC Berkeley. The admission rate for men was 44% and for women was 35%, The difference was statistically different. Continue reading “Simpson’s Paradox”