Month: December 2017

Being Sleepy and Tired

There is a fantastic post by luysii on his Chemiotics II blog. In it, he discusses his theory that senescent cell may be producing mediators that cause chronic fatigue syndrome (CFS). I think it’s a fascinating idea.

CFS is a terrible disease, made worse by the fact that some physicians don’t believe that it exists. Trust me, it does.

An interesting things about the disease is that it tend to occur in high income countries, and almost never in developing countries, and that in my experience, it tends to occur in women from mid to higher socioeconomic strata. This is in contrast to fibromyalgia, which Continue reading “Being Sleepy and Tired”

Will We Cure Diabetes, Heart Disease, and Alzheimer’s Disease One Day?

FDA, in 2008, did something that many people thought was preposterous. They began requiring companies to prove that diabetes drugs they developed did not kill people. Actually, to be more specific, they required the companies to prove that the risk of dying on the drug was not more than 1.8X higher than not being on the drug.

This caused an uproar. To prove such a ridiculous thing, some companies howled, would Continue reading “Will We Cure Diabetes, Heart Disease, and Alzheimer’s Disease One Day?”

Rosacea and Tiny Mites

Mites scare me.

When I was an undergrad, working on fruit flies (I would sit in a coldroom, which was essentially a big refrigerator, injecting fruit fly eggs with a tiny glass needle I blew myself, making some of the very early transgenic fruit flies), mite infestations would occasionally sweep through the lab, killing hundreds of thousands of fruit flies. Some of the flies represented years of work by students and postdocs.

Which brings us to rosacea. Continue reading “Rosacea and Tiny Mites”

It’s a Shame that Scientists Develop Drugs, Instead of Engineers

Museum of Natural History. That’s a funny name, isn’t it? The whole building is full of scientific and biological items like skeletons and fossils. Where’s the history part?  Shouldn’t it be called Museum of Science? Most people would put science and history on the opposite end of the spectrum.

When you hear a name like that, it almost feels like someone’s trying to obfuscate, trying to Continue reading “It’s a Shame that Scientists Develop Drugs, Instead of Engineers”

How Hedge Funds Make Money on Warrants

I’ve been CEO of two public companies, and on the board of several other public companies. It’s always puzzled me a bit how hedge funds made money on warrants.

When a small biotech company raises money, it often has to offer warrants in order to raise capital. For example, it might sell 10 million shares of stock (usually at a discount to market, let’s say of 10%), and offer

Continue reading “How Hedge Funds Make Money on Warrants”