FDA, in 2008, did something that many people thought was preposterous. They began requiring companies to prove that diabetes drugs they developed did not kill people. Actually, to be more specific, they required the companies to prove that the risk of dying on the drug was not more than 1.8X higher than not being on the drug.
This caused an uproar. To prove such a ridiculous thing, some companies howled, would Continue reading “Will We Cure Diabetes, Heart Disease, and Alzheimer’s Disease One Day?”
Mites scare me.
When I was an undergrad, working on fruit flies (I would sit in a coldroom, which was essentially a big refrigerator, injecting fruit fly eggs with a tiny glass needle I blew myself, making some of the very early transgenic fruit flies), mite infestations would occasionally sweep through the lab, killing hundreds of thousands of fruit flies. Some of the flies represented years of work by students and postdocs.
Which brings us to rosacea. Continue reading “Rosacea and Tiny Mites”
Museum of Natural History. That’s a funny name, isn’t it? The whole building is full of scientific and biological items like skeletons and fossils. Where’s the history part? Shouldn’t it be called Museum of Science? Most people would put science and history on the opposite end of the spectrum.
When you hear a name like that, it almost feels like someone’s trying to obfuscate, trying to Continue reading “It’s a Shame that Scientists Develop Drugs, Instead of Engineers”
“All I wanted was the opportunity to fail” – Jack Goeken, Founder of MCI
You can’t have successes without risking failure
When medical students are taught about appendicitis, we are taught that 20% of the appendectomies should find that the appendix does not need to removed. In other words, we should have such a low threshold for surgery that in 20% of the cases, we should be wrong. If only 10% of the surgeries are wrong, we are killing patients because Continue reading “Power of Failure”
Simpson’s Paradox is one of the classic paradoxes, made famous by the UC Berkeley’s experience,
In 1973, the admission rate for men and women were noted to be very different for UC Berkeley. The admission rate for men was 44% and for women was 35%, The difference was statistically different. Continue reading “Simpson’s Paradox”
Lord’s Paradox, which is a special instance of Simpson’s Paradox, is as follows (excerpted from Lord’s original paper): Continue reading “Lord’s Paradox”
In drug development, there are certain terms that people throw around that signifies that they know something about a field they’re not an expert in. These are shorthands for asking, is that compound any good?
“What’s the p-value?” (buzzword for clinical data)
“Does it meet Lipinski’s Rule of Five?” (buzzword for medicinal chemistry)
“What’s the IC50?” (buzzword for Continue reading “IC50 Means Nothing”