These are some of the most important papers I have read, mostly relating to drug development, others relating to science in general. They are not the papers that are widely recognized as being important, but instead, they are important but unrecognized papers–papers that are considered oddities.
These are important not just because they relate to an important discovery but because they run against the current scientific thinking. These are papers that are often ignored because they upset the dominant thinking among scientists and accepting them would mean that many current theories and experiments might need to be discarded or rethought.
Antioxidants prevent health-promoting effects of physical exercise in humans
Dispensing Processes Impact Apparent Biological Activity as Determined by Computational and Statistical Analyses
DNA charge transport as a first step in coordinating the detection of lesions by repair proteins
Male Scent May Compromise Biomedical Research
Regulatory perspectives of Type II prodrug development and time-dependent toxicity management
The Environment and Disease: Association or Causation?
Widespread intraspecies cross-contamination of human tumor cell lines arising at source
Why most published papers are false
Antibodies used as reagents are unreliable
Chemistry: Chemical con artists foil drug discovery
A large fraction of HLA class I ligands are proteasome-generated spliced peptides
False Negative Rate of 70% in Functional MRI Software
There is no limit to human lifespan
It really matters (a lot) when you give a drug (and this is a lay explanation of the concepts)
Synthetic Lethality to the Third Power
Mutations (Alone) Don’t Cause Cancer
Why BRAF inhibitors don’t work in colon cancer. Or, the limitations of target-based drug development
Protein Phase Separation: A New Phase in Cell Biology
Time of Day Affects Drug Efficacy
Gut microbiome modulates efficacy of immune checkpoint inhibitors
Understanding is a Poor Substitute for Convexity